ARRHYTHMOGENIC DRUGS CAN AMPLIFY SPATIAL HETEROGENEITIES IN THE ELECTRICAL RESTITUTION IN PERFUSED GUINEA-PIG HEART: AN EVIDENCE FROM ASSESSMENTS OF MONOPHASIC ACTION POTENTIAL DURATIONS AND JT INTERVALS.

Non-uniform shortening of the action potential duration (APD90) in different myocardial regions upon heart rate acceleration can set abnormal repolarization gradients and promote arrhythmia.This study examined whether spatial heterogeneities in APD90 restitution can be amplified by drugs with clinically proved proarrhythmic potential (dofetilide, q

Hierarchical processing is pervasive in Dog Kibble the brain, but its computational significance for learning under uncertainty is disputed.On the one hand, hierarchical models provide an optimal framework and are becoming increasingly popular to study cognition.On the other hand, non-hierarchical (flat) models remain influential and can learn effi

Adaptation is thought to proceed in part through spatial and temporal changes in gene expression.Fish species such as the threespine stickleback are powerful vertebrate Video Receivers models to study the genetic architecture of adaptive changes in gene expression since divergent adaptation to different environments is common, they are abundant and